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Breast Imaging Case of the Day

¹ Departments of Radiological Sciences (D.C.)
² Pathology (P.M.C.)
³ University of California, Irvine Medical Center (N.B.R.), 101 The City Drive, Orange, CA 92868-3298.

View larger version (70K): [in a new window]   Figure 1a.  (a, b) Craniocaudal (a) and mediolateral oblique (b) mammograms of the left breast demonstrate a 1.5-cm multilobulated, spiculated mass in the upper outer quadrant. (c) Coned compression magnification view in the mediolateral projection also demonstrates faint punctate microcalcifications. The original mammograms (not shown) demonstrated approximately 10 microcalcifications.

View larger version (90K): [in a new window]   Figure 1b.  (a, b) Craniocaudal (a) and mediolateral oblique (b) mammograms of the left breast demonstrate a 1.5-cm multilobulated, spiculated mass in the upper outer quadrant. (c) Coned compression magnification view in the mediolateral projection also demonstrates faint punctate microcalcifications. The original mammograms (not shown) demonstrated approximately 10 microcalcifications.

View larger version (100K): [in a new window]   Figure 1c.  (a, b) Craniocaudal (a) and mediolateral oblique (b) mammograms of the left breast demonstrate a 1.5-cm multilobulated, spiculated mass in the upper outer quadrant. (c) Coned compression magnification view in the mediolateral projection also demonstrates faint punctate microcalcifications. The original mammograms (not shown) demonstrated approximately 10 microcalcifications.

View larger version (184K): [in a new window]   Figure 2a.  (a) Low-power photomicrograph (original magnification, x40; hematoxylin-eosin stain) shows glandular structures of varying sizes (adenosis) with the smaller glands compressed by surrounding stromal sclerosis. (b) Low-power photomicrograph (original magnification, x40; immunoperoxidase stain with monoclonal antibody HHF-35) demonstrates a layer of cells immunoreactive for muscle actin around each of the small glands. The presence of these myoepithelial cells suggests a benign process (adenocarcinoma of the breast usually has no myoepithelium).

View larger version (183K): [in a new window]   Figure 2b.  (a) Low-power photomicrograph (original magnification, x40; hematoxylin-eosin stain) shows glandular structures of varying sizes (adenosis) with the smaller glands compressed by surrounding stromal sclerosis. (b) Low-power photomicrograph (original magnification, x40; immunoperoxidase stain with monoclonal antibody HHF-35) demonstrates a layer of cells immunoreactive for muscle actin around each of the small glands. The presence of these myoepithelial cells suggests a benign process (adenocarcinoma of the breast usually has no myoepithelium).