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DOI: 10.1148/rg.265055090
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RadioGraphics 2006;26:1517-1531
© RSNA, 2006


EDUCATION EXHIBIT

Cerebral Amyloid Angiopathy: CT and MR Imaging Findings1

Christine P. Chao, MD, Amy L. Kotsenas, MD and Daniel F. Broderick, MD

1 From the Department of Radiology, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL 32224. Recipient of a Certificate of Merit award for an education exhibit at the 2004 RSNA Annual Meeting. Received April 17, 2005; revision requested July 12 and received September 8; accepted September 14. All authors have no financial relationships to disclose. Address correspondence to A.L.K. (e-mail: kotsenas.amy{at}mayo.edu).

Cerebral amyloid angiopathy (CAA) is an important but underrecognized cause of cerebrovascular disorders that predominantly affect elderly patients. CAA results from deposition of ß-amyloid protein in cortical, subcortical, and leptomeningeal vessels. This deposition is responsible for the wide spectrum of clinical symptoms and neuroimaging findings. Many cases of CAA are asymptomatic. However, when cases are symptomatic, patients can present with transient neurologic events, progressive cognitive decline, or potentially devastating intracranial hemorrhage. Computed tomography is the imaging study of choice for evaluation of suspected acute cortical hemorrhage, which may be accompanied by subarachnoid, subdural, or intraventricular hemorrhage. Magnetic resonance imaging is best suited for identification of small or chronic cortical hemorrhages and ischemic sequelae of this disease, exclusion of other causes of acute cortical-subcortical hemorrhage, and assessment of disease progression. Accurate recognition of imaging findings is important in guiding clinical decision making in patients with CAA.

© RSNA, 2006







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