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Multiple Endocrine Neoplasia: Spectrum of Radiologic Appearances and Discussion of a Multitechnique Imaging Approach¹

¹ From the Department of Radiology, Churchill Hospital, Oxford Radcliffe NHS Trust, Oxford, England (A.F.S., F.V.G., R.R.P.), and the Academic Endocrine Unit, Nuffield Department of Medicine (R.V.T.) and the Department of Clinical Endocrinology (J.A.H.W.), Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, England. Recipient of Certificate of Merit and Excellence in Design awards for an education exhibit at the 2004 RSNA Annual Meeting. Received March 30, 2005; revision requested May 3 and received June 22; accepted June 23. R.V.T. is supported by the Medical Research Council of England; all remaining authors have no financial relationships to disclose. Address correspondence to A.F.S., Department of Radiology, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, England (e-mail: andyscarsbrook1{at}aol.com).

Multiple endocrine neoplasia (MEN) is characterized by the occurrence of two or more tumors that may be associated with hyperfunction and malignancy. MEN is caused by genetic defects, and two major types, MEN 1 and MEN 2, are recognized. Each type is characterized by the development of tumors within specific endocrine organs. A multidisciplinary approach involving cooperation between endocrinologists, surgeons, oncologists, and radiologists is pivotal for optimizing patient treatment. Imaging plays a vital role in the diagnosis and management of the disease. To contribute effectively, however, the radiologist must understand the range of anatomic and functional imaging modalities used in the assessment of endocrine disorders. In addition, knowledge of the optimal techniques for evaluating the pituitary, thyroid, parathyroid, pancreatic, adrenal, and foregut carcinoid tumors that occur in these MEN syndromes is essential. Finally, an understanding of the spectrum of disease and of the manifestations of each component is crucial for accurate detection, staging, and surveillance in this diverse patient group.

© RSNA, 2006

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